Like most endocrine disorders, PMS involves the disruption of more than just one hormone. True, estrogen tends to be higher in women with PMS, especially during the second half of her menstrual cycle. However, progesterone is also lower than usual, FSH overshoots on some days, aldosterone increases prior to menses and hypothyroidism is more common in women suffering from PMS.

Because of the complexity and individuality of this condition, therapies vary from woman to woman. Vitamin E helps reduce fatigue, insomnia and headaches. B-complex, especially B6, ameliorates PMS symptoms in general. Because magnesium deficiency affects the adrenals and aldosterone levels (and thus bloating), this mineral may be beneficial. Unicorn root, Aletris farinosa, historically known as an herb for "poor ovarian function", has estrogen-like qualities so may be helpful.