Monosodium Glutamate (MSG) is a single sodium salt of glutamic acid. This seaweed extract, now commonly produced chemically, may suggest the possible toxicity of glutamic acid as slightly neurologically irritating in high dosages. Some people seem to be particularly sensitive to glutamine and MSG. Otherwise, glutamine is relatively safe and is the best way to supplement this amino acid.

GABA itself has been used in the treatment of epilepsy, high blood pressure, and anxiety, as it helps in relaxation. GABA may also enhance the sex drive and reduce nighttime urination.