Dec 11, 2002 (Washington, DC) The federal government today published its biennial "Report
on Carcinogens", adding steroidal estrogens used in
estrogen replacement therapy and oral contraceptives to its
official list of "known" human carcinogens. This and 15
other new listings bring the total of substances in the
report, "known" or "reasonably anticipated" to pose a
cancer risk, to 228.
This, the tenth edition of the report, was forwarded to
Congress and released to the public today by the Department
of Health and Human Services. It was prepared by the
National Toxicology Program, an arm of the HHS located at
the National Institute of Environmental Health Sciences,
one of the National Institutes of Health. The reports are
published every two years after lengthy study and
scientific reviews by three successive expert panels of
government and non-government scientists.
In a statement releasing the report, HHS Secretary Tommy
Thompson today thanked "the hundreds of scientists who have
contributed to this report through their original research
or their careful reviews of these important studies. The
public is well served by this dispassionate report that
helps all of us ensure that the American public is made
aware of potential cancer hazards."
The tenth report newly lists the group of hormones known as
steroidal estrogens as "known human carcinogens." A number
of the individual steroidal estrogens were already listed
as "reasonably anticipated carcinogens" in past editions,
but this is the first report to so list all these hormones,
as a group. As with all the other medications listed, the
"Report on Carcinogens" does not address or attempt to
balance potential benefits of use of these products.
Also newly listed as "known" causes of cancer in humans are
broad spectrum ultraviolet radiation, whether generated by
the sun or by artificial sources; wood dust created in
cutting and shaping wood; nickel compounds and beryllium
and its compounds commonly used in industry. Beryllium and
beryllium compounds are not new to the list but was
previously listed as "reasonably anticipated to be a human
carcinogen."
The report is mandated by Congress as a way for the
government to help keep the public informed about
substances or exposure circumstances that are "known" or
are "reasonably anticipated" to cause human cancers. The
report also identifies current regulations concerning these
listings in an attempt to address how exposures have been
reduced.
The report makes a distinction between "known" human
carcinogens, where there is sufficient evidence from human
studies and "reasonably anticipated" human carcinogens,
where there is either limited evidence of carcinogenicity
from human studies and/or sufficient evidence of
carcinogenicity from experimental animal studies.
The report does not assess the magnitude of the
carcinogenic risk, nor does it address any potential
benefits of listed substances such as certain
pharmaceuticals. Listing in the report does not establish
that such substance presents a risk to persons in their
daily lives. Such formal risk assessments are the
responsibility of Federal, State, and local health
regulatory agencies.
NEWLY LISTED AS KNOWN HUMAN CARCINOGENS ARE:
STEROIDAL ESTROGENS. These are a group of related hormones
that control sex and growth characteristics and are
commonly used in estrogen replacement therapy to treat
symptoms of menopause and in oral contraceptives. The
report cites data from human epidemiology studies that show
an association between estrogen replacement therapy and a
consistent increase in the risk of endometrial cancer
(cancer of the endometrial lining of the uterus) and a less
consistent increase in the risk of breast cancer.