J Pharm Pharmacol 1987 Jul;39(7):567-9
The anti-inflammatory activity of a polysaccharidic fraction (EPF) obtained
from Echinacea angustifolia roots has been examined using the carrageenan paw
oedema and the croton oil ear test. EPF (0.5 mg kg-1 i.v.) almost inhibited
the carrageenan-induced oedema over 8 h and furthermore, EPF, topically
applied, inhibited mouse ear oedema induced by croton oil. EPF also reduced
the leukocytic infiltration of the croton oil dermatitis, evaluated both as
peroxidase activity and histologically. After topical application EPF appears
to be slightly inferior in potency to indomethacin. The results suggest that
the anti-inflammatory activity of E. angustifolia resides in its
polysaccharidic content.
Voaden D and Jacobson M:
Tumor inhibitors. 3. Identification and synthesis of an oncolytic hydrocar
bon from American coneflower roots.
J Med Chem 15:619-23, 1972
Wacker A Hilbig W
[Virus-inhibition by echinacea purpurea (author's transl)]
Planta Med 1978 Feb;33(1):89-102 (Published in German)
Wagner V, Proksch A, Riess-Maurer, et al:
Immunostimulating polysaccharides (heteroglycanes) of higher plants -
preliminary communications. Arzneim Forsch 34:659-660, 1984
[Proceedings: Echinacea activates the properdin system]
Echinacea aktiviert das Properdinsystem
Med Monatsschr 1976 Jan;30(1):32-3 (Published in German)
