Some women suffer repeated, early miscarriage, even at a relatively young age. They often have similar nutritional profiles: they can have elevated plasma homocysteine levels, often twice the upper limit of normal, and low RBC and plasma folate concentrations are also common.
So how can this problem be treated? One way is folic acid and B6 supplementation. It was tried out in one study on 25 women, aged between 20 and 37 years with no children and with a history of between three and five miscarriages.
Each was given 15 mg a day of folic acid and 750 mg a day of B6 for one month. Within three months, 22 of the 25 had become pregnant and, of those, 20 had successful pregnancies to full term. Three months after the births, the folic acid dose was reduced to 5 mg a day, and B6 was discontinued. Nine additional pregnancies, which all went to full term, were subsequently announced.
(Source: Fertility and Sterility, 2001; 75: 823-5).